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Data from rat studies has likewise demonstrated an increased risk of thyroid C-cell carcinoma at high semaglutide doses
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It produced the only human in-vivo GLP-1 increase we could find in this category: a 2025 South Korean trial in 98 pre-diabetic adults reported GLP-1 rising from 26.62 pM to 30.38 pM alongside a 9.07% fall in fasting glucose
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